Endocrine Abstracts

CGRP, a potent vasodilator, is elevated in the intense periods during menopausal hot flushes and presently represents a candidate mediator of vasomotor symptoms. However due to the short half-life of CGRP, the local paracrine effects may be more important than systemic effects. These local paracrine effects may be mediated in conjunction with adipose tissue, due to close physical proximity with the vasculature; as well as altered oestrogen metabolism following menopause. There...